Key Benefit: Boosts NAD levels

NMN, or nicotinamide mononucleotide, is a molecule found naturally in certain foods, such as broccoli, edamame, and avocado. 

NMN is a vital building block in the process of cellular energy production. It serves as a raw material that converts into NAD+. That is another molecule crucial for fuelling essential processes in your body, such as metabolism, DNA repair, and cellular maintenance. Without NAD (nicotinamide adenine dinucleotide), you would be dead in 30 seconds! NAD was discovered in the early 20th century as an alcoholic fermentation enhancer. It was not until the 1990s that it was discovered that it was a central regulator of many major biological processes, including ageing and disease. NAD acts as a fuel for the seven sirtuins that regulate cells by turning genes on and off, repairing broken DNA strands etc. It's critical to have high levels of this regulator in your cells. The higher the NAD levels, the healthier and younger the cell is! 

 As we age, the levels of NAD+ in our bodies decrease, leading to the cells breaking down and the sirtuins not being able to do their jobs efficiently. Then various age-related issues creep in, such as arthritis, mental decline, diabetes, and skin deterioration. Worse still, the sirtuins, which play a vital role in sustaining genome integrity, simply get overwhelmed by the load imposed on them by the lack of NAD. They go rogue, i.e. cancerous and inflammatory. It's these rogues that cause so much damage and pain and eventually death. We don’t help NAD production by overindulging, be it drinking, smoking, eating processed food, not exercising etc.

Key Benefit: Mimics fasting

In 2002, antioxidants were the new craze for increasing lifespan. This has since been debunked, but billions are still spent each year on these antioxidants.

Resveratrol, however, a natural compound found in red grapes, berries, and peanuts, was a revelation. Yeast cells divide about 25 times before they die, but it was discovered by David Sinclair, PhD, and his team that yeast cells fed resveratrol would divide up to 35 times! Meaning that they were living on human terms for an extra 50 years. It was as if they were calorie-restricted, like fasting. Remember, the yeast cell is identical to our cells. Evolution simply joined billions of them together, and the sirtuins programmed them to act differently i.e. skin cells, brain cells etc. Resveratrol is a compound that fooled cells into believing they were starving and needed to hunker down, repair DNA etc. 

If you plan to increase your red wine intake, it is worth noting that you would have to drink 200 bottles of red wine per day to obtain the 1g we provide.

Key Benefit: Enables DNA repair

Trimethylglycine (TMG), or betaine, is a fascinating molecule. It bolsters NMN absorption and effectiveness in natural and supplemental forms. It can be found in beetroot, spinach, and seafood. It is important for the body's internal chemistry. TMG can be thought of as a multi-talented technician who works behind the scenes in various vital processes.

TMG is a crucial substance that supports methylation, a fundamental chemical reaction that enables DNA repair, energy production, and detoxification. TMG facilitates this process by donating methyl groups, which function as tiny chemical tools, to other molecules. This helps them function correctly and promotes healthy cells, efficient metabolism, and optimal liver function. Moreover, TMG acts as an osmolyte, which means it helps cells manage their water balance in salty environments. 

TMG has a range of potential health benefits, which include enhancing athletic performance, protecting the liver, and promoting mood regulation.

You could obtain 500mg daily by consuming foods like raw spinach (boiling reduces the TMG content considerably); however, it would require a conscious effort.

Key Benefit:  Kills senescent cells

Fisetin is a naturally fermented product. It is a vibrant yellow pigment found in strawberries, apples, and grapes. This pretty plant flavonoid significantly impacts health and longevity. It acts like a microscopic gardener, using various tools to tend to your cellular landscape. Fisetin is the most effective zombie cell killer. Curcumin is not far behind in a close second.

Zombie cells are formally called senescent cells. Fisetin acts as a "senolytic" compound, eliminating zombie cells which are aged, malfunctioning cells that cause inflammation and hinder vital processes. We all have millions of zombie cells, and the younger the body, the less chance that the zombie cells can be removed before they go rogue. That is why children can contract deadly cancers from a simple gene irregularity and failure of the natural vibrant process to rid the body of the rogue cells. Fisetin removes these unwanted guests, promoting cellular rejuvenation and contributing to healthier ageing.

You could obtain the same daily dose of fisetin that we provide by consuming considerable amounts of strawberries (strawberries have a higher concentration of fisetin than other fruits and vegetables) throughout the year. However, this would require a conscious effort and an awfully large number of strawberries. Imagine recognises the importance of Fisetin and the best form of it, so we give you what you really should have!

Key Benefit:  Boosts cell performance

We're plagued by zombie cells (formally called senescent cells) like radioactive waste. Evolution hasn't caught up with our whack-a-mole approach to medicine, they are popping up faster than nature can catch up and help remove more senescent cells. If you place a small amount of zombie cells under a mouse's skin, in no time, the mouse is covered in zombie cells accelerating the decline of life.

James Kirkland from the Mayo Clinic was able to eliminate the zombie cells in mice and extend their lives by 36% with a quick course of two senolytic compounds: Quercetin (found in red onions, kale and capers) and the senolytic synthetic drug dasatinib.

Quercetin is especially beneficial for allergies, arthritis, and asthma, where chronic inflammation is a significant factor. In addition, it may enhance exercise performance, boost the immune system, and protect the brain from age-related decline.

Quercetin is found in apples, red onions, kale and capers. If you plan to simply increase your apple intake, it is worth noting that you would have to eat around a hundred apples per day to achieve the 500mg we provide.

Key Benefit:  Energises sirtuins

Ca-AKG is considered a safe and stable form of the naturally occurring substance alpha-ketoglutarate (AKG) produced by our bodies until around age 40, after which, like NMN, it radically decreases. Calcium Ketoglutarate (Ca-AKG) is not your average calcium supplement. It is a unique blend of calcium, essential for strong bones and teeth, and alpha-ketoglutarate (AKG), a molecule involved in energy production and cellular processes. This combination is like a dynamic duo that benefits your body in multiple ways.

The calcium in Ca-AKG is in a chelated form, which means it is bound to AKG. This binding makes it easier for your body to absorb and utilise calcium. This enhanced absorption can be particularly beneficial for individuals with digestive issues or those concerned about osteoporosis. It ensures that they get the necessary calcium for maintaining healthy bones.

Ca-AKG can boost energy levels, reduce fatigue, and improve athletic performance. AKG also possesses antioxidant and anti-inflammatory properties, which protect against cellular damage and age-related decline. Ca-AKG has the added advantage of going to where it is needed, the bones, not your arteries. 

Calcium Ketoglutarate cannot be obtained in significant amounts in foods we eat.

Key Benefit:  Triggers autophagy

Spermidine is a molecule that occurs naturally in wheat germ, soybeans, and cheese. It is not just an ordinary nutrient but a cellular janitor that helps keep things clean and efficient within our cells. 

Its primary ability is to trigger autophagy, a process of cellular recycling. This process involves taking zombie cells and recycling parts that are needed in times of stress. Stress is our longevity nemesis, so we need to keep it within guidelines. Too much and permanent damage can occur e.g. fasting for a month!! We’re back to the cell wanting to survive and over billions of years. It's learned to get us to 80 years and whales to 200. So spermidine clears out damaged proteins and worn-out cell parts, making space for new and healthy components.

If you plan to increase your wheatgerm (food with the highest spermidine levels) intake, you would have to consume around 400g daily - that’s much more than a sprinkle on your cereal!

Key Benefit:  Helps Calcium absorption

Vitamin D3 often called the "sunshine vitamin," is more than just a mood booster on gloomy days. This fat-soluble nutrient can be found in foods like fatty fish and eggs and plays a crucial role in various bodily functions, making it essential for maintaining optimal health. Think of it as a conductor orchestrating a harmonious symphony within your body.

Vitamin D3 plays a crucial role in assisting calcium absorption in the body. It acts as a key, enabling the efficient absorption of calcium from the gut, which is then transported to the bones and teeth. This helps maintain their strength and resilience, preventing the onset of osteoporosis, a condition that causes the weakening of bones and an increased risk of fractures. 

Vitamin D3 has numerous benefits beyond supporting bone health. It regulates insulin secretion, supports immune function, and influences mood and brain health. It may even prevent certain cancers, autoimmune diseases, and depression. 

Our bodies can naturally produce Vitamin D3 when we are exposed to sunlight. However, certain factors, like the use of sunscreen, limited time spent outdoors, and darker skin pigmentation, can impede this process. Therefore, it becomes essential to supplement Vitamin D3, especially during winter or for individuals with limited sunlight exposure.

If you want to increase your egg intake and obtain the amo

Key Benefit:  Binds calcium to bones

Although Vitamin K1 is often the subject of attention due to its role in blood clotting, Vitamin K2 plays an equally key role in supporting bone and heart health. Think of it as a proficient architect, carefully directing calcium to where it belongs in your bones while keeping it away from your arteries.

K1 and K2 are two types of vitamin K, with K1 primarily found in leafy green vegetables and K2 found in animal products like eggs and cheese, as well as fermented foods like miso and sauerkraut. K2 comes in two distinct forms, MK-4 and MK-7, which offer different bodily benefits and have different lifespans. MK-4, found in animal products, is known for strengthening bones, while MK-7, prevalent in fermented foods, is known for protecting the heart.

Vitamin K2's magic trick is its targeted calcium management. It activates osteocalcin, a protein that binds calcium to your bones, making them dense and strong. This helps to significantly reduce the risk of fractures and osteoporosis, especially in postmenopausal women. Additionally, K2 activates another protein called MGP, which prevents calcium buildup in your arteries. This is particularly important as it can help to reduce the risk of heart disease and stroke significantly.

Naturopathic doctor Kate Rheaume-Bleue describes the role of vitamin K2 succinctly in her book, Vitamin K2 and the Calcium Paradox.

 “Vitamin K2 funnels calcium into bones to strengthen mineral density and fight fractures while it prevents and even removes dangerous arterial calcification. Along the way, it has beneficial effects for almost every major health concern of our time, including diabetes, cancer, Alzheimer’s disease, infertility, tooth decay and growing healthy children.” 

If you plan to increase your cheese intake, you would need to consume around 2.5 kg per day to obtain 1.5mg.

Key Benefit:  Holds cells together

The ubiquitous Vitamin C is a most fascinating vitamin. From the tales of Magellan and Cook travelling the world 500 years ago up until the 18th century, the number of sailors who perished from a lack of vitamin C was alarming. They literally fell apart! The sailors who ate the rats on board ships survived. This was because vitamin C held the cells together, and while rats can retain vitamin C, we can't. Magellan survived because his loving wife gave him pots of jam to take with him. He cherished it and had a little each day, not knowing it was saving his life!

Vitamin C is found in many fruits and vegetables, such as oranges, berries, bell peppers, and broccoli. This vitamin is like a tireless cheerleader for your cells, helping to boost their defences, keep them healthy and full of vitality, and, more importantly, stop your teeth from falling out!

Vitamin C is not just crucial for boosting your immune system. It possesses remarkable antioxidant abilities, acting as a tiny shield that repels harmful free radicals. These molecules can cause cellular damage, resulting in ageing and chronic diseases such as cancer and heart disease. By neutralising these threats, Vitamin C effectively safeguards your DNA, proteins, and membranes, thus promoting healthy and resilient cells.

Vitamin C also plays a crucial role in collagen production, the protein responsible for forming the structure of your bones, skin, blood vessels, and cartilage. Vitamin C acts as an architect, overseeing the creation of strong and flexible structures throughout your body. This makes it essential for wound healing, maintaining firm and elastic skin, and supporting joint health.

As research continues, Vitamin C's antioxidant and collagen-boosting powers are undeniable. Regular intake is crucial since your body cannot store this vital vitamin.

If you plan to increase your orange intake, you would have to consume around 10 oranges daily to obtain 500mg of Vitamin C.

Key Benefit:  Provides cells with energy

Taurine is the bouncy, energetic life of every party in the body's cellular world. She's a ball of energy, buzzing around with her trademark glow of bright yellows and golds. Wherever she goes, fatigue and exhaustion scatter, unable to keep up with her boundless vigour.

Taurine occurs naturally and is abundant in foods like oysters, mussels, pumpkin seeds, and your body. 

Taurine plays a crucial role in bile acid production, which helps digestion and absorption of nutrients. Additionally, it regulates blood sugar levels and keeps our energy levels stable. Studies also suggest that it can enhance athletic performance and improve brain function.

While your body naturally produces taurine, stress, illness, and even vegan diets can deplete its levels.

Taurine diminishes with age. It has been proven that monkeys taking regular daily doses can live at least 10% longer. Translated to humans, this would mean that if everyone took taurine, the average life expectancy would increase to 95-100. 

Taurine is a magical substance with multiple benefits for our bodies. This amazing substance occurs naturally and is abundant in foods like oysters, mussels, pumpkin seeds, and your body. Taurine plays several essential roles in maintaining good health, acting as a diligent multitasker in the background. Imagine it as a quiet conductor, ensuring smooth functions within your cells.

To get 1.5g of Taurine, you would need to consume around half a kg of seafood or chicken or several litres of yoghurt or milk.

Taurine is known for calming the nerves and regulating nerve impulses, acting as a natural tranquilliser. It helps to calm overactive brains and can provide relief from anxiety. Additionally, Taurine can improve the quality of sleep. By protecting your cells, Taurine can help reduce inflammation and safeguard against chronic conditions such as heart disease and diabetes. 

Taurine plays a crucial role in bile acid production, which helps digestion and absorption of nutrients. Additionally, it regulates blood sugar levels and keeps our energy levels stable. Studies also suggest that it can enhance athletic performance and improve brain function.

While your body naturally produces taurine, stress, illness, and even vegan diets can deplete its levels.

Key Benefit:  Cell structural diva!

Collagen is the structural diva of the body, sashaying her way through tissues with confidence and poise. As the most abundant protein in the arena, she knows she's a star. With her lithe, fibrous frame tightly woven together, Collagen oozes strength and resilience.

Despite her lean and willowy appearance, don't let her slim figure fool you - collagen is one tough cookie. She provides the scaffolding that fortifies skin, bones, tendons and ligaments, giving their foundations unparalleled elasticity and durability. Without her reinforcements, the show couldn't go on.

But collagen's talents extend well beyond brute strength. She's a true Renaissance protein, playing roles throughout the body with versatile flair. Need some cushioning for the joints? No problem; her smooth movability has you covered. Or how about facilitating cellular renewal and repair? Consider it done with her meticulous construction abilities.

Collagen is the primary building block of your body's skin (the biggest organ in your body), muscles, bones, tendons and ligaments, and other connective tissues. Collagen is a protein that makes up one-third of your body's protein content. After all, your skin, the biggest organ in your body, accounts for a third of you.

Collagen is found in meat broths, sardines, berries, and broccoli. 

Collagen is like a network of tightly woven fibres that provide structure, strength, and elasticity to various tissues. In the skin, it acts as a supportive mesh, ensuring plumpness and youthful bounce. It's a crucial component of bones, giving them rigidity and structure. The muscles form the connective tissue that enables movement and power.

While your body naturally produces collagen, production decelerates in your thirties, contributing to wrinkles, joint pain, and weakened bones. 

You might be planning to increase your intake of beef bone broth - which, if consumed most days, will give you the 1g we recommend; however, if that’s not so appealing, we’ve got you!

Key Benefit:  Keeps neural pathways clear

The newcomer on the block. It’s taking the USA by storm!

Phosphatidylserine is the unflappable wise elder of the cellular village. With a serene, calming presence, this lipid sage walks the grounds, gently restoring order and tranquillity whenever chaos strikes.

While many other membrane compounds get flustered by stressful circumstances, phosphatidylserine maintains an aura of zen-like composure. The body turns to her when neurotransmitters are firing erratically, or hormones are raging out of control. With deft precision, she helps resettle the neuronal regions, coaxing them back into equilibrium.

Despite her easy-going demeanour, don't mistake this phospholipid for being fragile or weak. Phosphatidylserine is crafted with an inner strength and resilience that belies her mild manner. She's a tough nut to crack when it comes to withstanding the pressures and burdens of ageing or neurodegeneration.

Within every cell nucleus, you'll find phosphatidylserine's calming influence. She's the benevolent governor who presides over orderly cell life cycle processes like cell renewal, proliferation, and healthy cell death. Her dexterous guidance helps prevent cells from descending into chaos and mutation.

But even with all her heightened duties, phosphatidylserine remains utterly humble and nurturing at heart. You'll spot her gently ushering fresh molecules through cellular membranes while recycling older ones for new roles. She's a consummate multitasker, handling each task with a velvet touch.

Naturally found in the brain, she improves memory, promotes a sense of calmness and relaxation, and improves exercise performance, muscle damage and recovery. She is proven to help with symptoms of depression and anxiety. Some studies suggest it helps in age-related macular degeneration.

While not strictly an anti-ageing supplement, nonetheless, it is a perfect complementary one.

Phosphatidylserine is a type of phospholipid that is not very abundant in most foods we eat. However, there are a few food sources that contain small amounts of phosphatidylserine:

• Soy lecithin
• Egg yolks
• Organ meats e.g. liver and brain
• White mushrooms

To get 100mg of phosphatidylserine you would need to consume around five egg yolks.

Key Benefit:  Cell conductor

Imagine Magnesium Citrate and Magnesium Glycinate as two dedicated guardians of your well-being, each with unique strengths and personalities, working tirelessly to ensure your body thrives.

Magnesium Citrate is like an energetic and enthusiastic personal trainer. He’s always on the move, constantly motivating your digestive system to keep things running smoothly. His main goal is to make sure everything in your gut flows without a hitch, preventing any sluggishness. With a zest for life, he ensures that your bowels remain active and regular, sparing you the discomfort of constipation.

Not only does he take care of your digestion, but he also has a knack for energising your muscles. After a long day or an intense workout, he swoops in to relieve muscle cramps and spasms, ensuring you recover quickly. This dynamo doesn't stop there; it also plays a crucial role in supporting your heart health and maintaining a steady rhythm so you can stay active and healthy.

Magnesium Glycinate, on the other hand, is the epitome of calmness and nurture. Picture a soothing caregiver who excels in providing tranquillity and relaxation. Her primary mission is to ease your mind and help you achieve restful sleep. With a gentle touch, she alleviates anxiety and stress, ensuring that your nights are peaceful and your days are filled with clarity and focus.

But her nurturing doesn't end with mental tranquillity. She's also a steadfast protector of your bones, working quietly to enhance bone density and strength. Her influence extends to your muscles as well, reducing tension and ensuring they function smoothly. In every aspect, she is dedicated to maintaining a balanced and harmonious environment in your body.

Key Benefit:  Removes dead cells

Curcumin is the fiery, vibrant diva of the antioxidant world. This bold spice struts onto the cellular scene draped in a showstopping gown of brilliant yellows and oranges. Wherever she goes, she simply commands attention with her dazzling presence. 

Despite her demure roots as a humble turmeric pigment, curcumin is no shrinking violet. She's a true bombshell with some serious anti-inflammatory swagger. This bodacious molecule has caught the eye of many a research study, all vying for her multifarious talents.

On the antioxidant stage, curcumin gives one heck of a performance. She unleashes a fearsome volley of free radical-quenching abilities, leaving oxidative stresses utterly vanquished in her wake. Her dance moves are simply mesmerizing as she twirls through lipophilic and hydrophilic domains alike with equal aplomb.

But Curcumin's star power extends well beyond her heroic antioxidant acts. She's a true triple threat who can effortlessly toggle between biochemical roles. One moment, she's boosting brain power and staving off cognitive decline, the next, she's bringing the body's inflammatory responses into perfect balance.

While she clearly relishes the spotlight, curcumin hasn't let her fame go to her head. In fact, she goes out of her way to boost the performances of other antioxidants in her troupe through biochemical symbiosis. She's the ultimate ensemble player, making sure every cellular melody sings in harmony.

To get around 1 gram of curcumin from food sources, you would need to consume a significant amount of turmeric, as curcumin is the primary active compound found in turmeric.

Fresh turmeric root contains 3-5% curcumin by weight. To consume it, you'd need to consume 20-33 grams or six teaspoons.

Key Benefit:  Fights oxidation

Alpha Lipoic Acid (ALA) is the body's fearless antioxidant superhero, swooping in to save cells from the dastardly clutches of free radicals and oxidative damage. This mighty molecule dons a daring yellow suit, ready to leap into action at a moment's notice.

But ALA's superpowers extend well beyond just battling baddies. She's also a defender of renewal, helping recycle and regenerate depleted supplies of other antioxidant heroes like vitamins C and E. She's the ultimate team player in the fight against oxidation. She neutralises free radicals, helps metformin regulate sugar, supports nerve function and relieves diabetic neuropathy. It has a few other good properties you can research yourself.

ALA was the first supplement David Sinclair studied. He did his PhD on it and has taken it daily for 20 years!

There are a few food sources that contain small amounts of ALA:

• Yeast extract spreads like Marmite and Vegemite
• Tomato juice and tomato sauce
• Organ meats e.g. liver and brain
• Spinach

To get 300mg of ALA, you would need to consume around 15-20 tablespoons of Marmite or 2 litres of tomato juice.

Key Benefit:  Assist absorption

According to several studies, Piperine can increase the absorption of resveratrol by up to 2000%. Adding a pinch of pepper to your resveratrol can significantly improve its effectiveness.  

Piperine, present in black pepper, is the smooth-talking wingman that helps resveratrol really make an entrance. While resveratrol may be the healthy heartthrob molecule that everyone wants around, it can be a bit shy - having trouble getting absorbed and making its full impact felt. That's where the charismatic piperine comes in.

This suave black pepper extract works some behind-the-scenes magic to help boost resveratrol's bio-availability. Piperine is the ultimate host, ushering resveratrol through the velvet ropes and past the body's strict bouncer defences so it can mingle where it matters most.

With his disarming confidence, piperine charms the cellular targets, convincing them to allow more of the dashing resveratrol to slip through the membranes uncontested. He's like the consummate party promoter, talking up resveratrol's many benefits and making sure it gains easy entry.

Piperine's powers of persuasion tremendously amplify resveratrol's availability, allowing it to work its antioxidant brilliance and deliver its potential anti-ageing and anti-inflammatory effects to more areas. What could have been just a mediocre showing becomes the smashing success of a soiree.

So while resveratrol may be the acclaimed guest of honour, it's the charming piperine that helps rally the welcoming committee and ensure this VIP gets the grand bio-absorptive reception it deserves throughout the body's cells. With a wingman like piperine on its side, resveratrol's health potential can truly go far.